In my forty years of entrepreneurship endeavors (manufacturing, business services, legal services, political action, charitable, and research and development) or my doctoral research, I have found a way to remove much of the anxiety of business through eco-systems of support. We all rely upon eco-systems to get us through life-challenges whether the nature of the life-challenge is economic, social, political, or some other dimension. Supportive eco-systems are described as coping skills, resources, and mentored relationships that are found within the spiritual, emotional, social, cultural, intellectual, environmental, political, economic, physical, and recreational dimensions. These supportive eco-systems allow us to apply the coping skills of faith or belief in what we are doing, self-change management, immersion of focus, empowerment, and endurance through life-challenge training. Much of what we do as entrepreneurs is based on these five coping skills and the attitudes we have towards our products and services, stakeholder audiences, and ourselves (resources) along with the depth of our relationships with people.