My understanding of your business is that you are targeting the US as a market for your product. Questions that readily pop up based on the nature of your business are these- Do you have a business presence in the US? Or are you operating through agents? What Latin American countries are you operating from? Business Presence in the US If you do have a US business presence (like for instance operating through an office in the US, or registering an entity and having a registered address, or having one of your employees in the US marketing your products to US clients), you will find yourself generating US income which is subject to US tax. You also need to consider state taxes. In 2018, the Supreme Court decision in South Dakota v. Wayfair made it possible for many states to start claiming sales tax from remote sellers. If you are operating through agents and they are not independent, that is as good as maintaining a physical presence. Latin American Countries in Question The country you are operating from is crucial because there could be bilateral tax agreements between that country and the US. So for instance, if you have no physical presence in the US, your customers will be obligated to withhold taxes on payments made to you. Bilateral tax agreements benefit you by reducing or even eliminating the amount that can be withheld from those payments. As for your US clients, if they are for-profit businesses, they are entitled to deduct the payment for your services from their income. My take The answer to your question depends on your peculiar business model and how you operate, plus the nature of your interaction with the US. If you need further clarification, please feel free to call.